USED UNCHAINED LABS BIG TUNA

The system supports both low-volume and mid-volume samples and can process up to 96 samples in parallel, making it ideal for formulation screening and process development.

It uses a pressure-driven UF/DF method with real-time volume monitoring, ensuring accurate buffer exchange, controlled concentration, and high reproducibility across all samples.

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Key Highlights

- Fully automated buffer exchange & concentration platform
- High-throughput: 24 or 96 samples simultaneously
- Volume range:
- 100–450 µL (Unfilter 96)
- 0.45–8 mL (Unfilter 24)
- Advanced pressure-based UF/DF technology (up to ~60 psi)
- Integrated ultrasonic volume sensing for precise control
- Supports protein concentration up to ~200 mg/mL
- Automated buffer addition & exchange cycle optimization
- High recovery rates (~96% sample recovery typical)
- Setup time typically <15–30 minutes
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Applications / Uses

- Protein formulation & buffer screening
- Monoclonal antibody (mAb) development
- Gene therapy (AAV, LNP, VLP processing)
- DNA / RNA sample preparation
- Biopharmaceutical process development
- Desalting and buffer exchange after purification
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Typical Specifications (Summary)

- Technology: Ultrafiltration / Diafiltration (UF/DF)
- Throughput: 24 or 96 samples/run
- Sample Types: Proteins, antibodies, nucleic acids, viral vectors
- Volume Range: 100 µL – 8 mL
- Pressure Range: Up to ~60 psi
- Mixing: Orbital shaking during filtration
- Automation: Full workflow automation (exchange + concentration)
- Sensors: Ultrasonic volume measurement
- Recovery: ~96% (application dependent)
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Typical Configuration Includes

- Big Tuna main system
- Unfilter 24 / Unfilter 96 plate compatibility
- Integrated liquid handling arm
- Pressure chamber (UF/DF module)
- Ultrasonic sensing system
- Control software workstation
- Tubing, tips, and accessories

Sameer Khanna

Sales Manager - BionexScientificUSA

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