The Pall Cadence BioSMB PD System is an advanced continuous multi-column chromatography platform designed for process development (PD) in biopharmaceutical purification workflows.
It utilizes simulated moving bed (SMB) technology to perform continuous purification, enabling higher efficiency compared to traditional batch chromatography. The system features a fully single-use flow path, allowing rapid setup, elimination of cleaning validation, and seamless scalability to GMP manufacturing systems.
The platform is specifically engineered to allow easy transition from process development to full-scale production without changing buffers, sorbents, or process parameters.
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Key Highlights
- Continuous multi-column chromatography (SMB technology)
- Fully single-use flow path (no cleaning validation required)
- Scalable from process development to GMP manufacturing
- Supports 1–16 columns (PD scale) for flexible operation
- Significant reduction in chromatography media (up to ~80%)
- Higher productivity vs batch chromatography (up to ~40% more binding capacity)
- Integrated valve cassette for automated operation
- Enables continuous processing of multiple chromatography steps
- Reduced buffer consumption and facility footprint
- Rapid flow-path replacement (single-use design)
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Applications / Uses
- Monoclonal antibody (mAb) purification
- Protein and biologics purification
- Continuous downstream processing development
- Process intensification studies
- Biopharmaceutical R&D and scale-up
- Integration with upstream bioprocessing systems
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Typical Specifications (Summary)
- Technology: Simulated Moving Bed (SMB) chromatography
- Flow Path: Fully single-use disposable system
- Column Capacity: Up to 16 columns (PD configuration)
- Operation Mode: Continuous multi-column chromatography
- Scalability: Direct scale-up to BioSMB Process (GMP system)
- Automation: Integrated valve cassette and control system
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Typical Configuration Includes
- BioSMB PD system base unit
- Integrated valve cassette
- Pump system and flow path
- Chromatography column setup (varies)
- Control software and workstation
- Tubing and single-use components
Sameer Khanna
Sales Manager - BionexScientificUSA
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Type: Chromatography Columns
