Thermo TSQ Endura Triple Quad LC/MS

15-Day
Refurbishment cadence
OEM-Spec
Verified against OEM and published benchmarks; report included.
On-Staff
Solution Scientists
Since 1996
Three decades supporting labs
What you are buying
A refurbished Thermo Scientific TSQ Endura Mass Spectrometer. Pair with a liquid chromatograph front end to build a quality LC/MS system.  GenTech rebuilds and tests the MS, the source, and the analyzer, then verifies the system end to end.
Every unit moves through the GenTech Certified process. Solution Scientists disassemble and inspect each module, replace all consumables and degraded wear components, then tune and calibrate the instrument and verify performance against OEM and published benchmarks using known reference chemicals. The instrument ships with its verification report. A certified-refurbished system gives you that performance without the capital cost or the lead time of a new purchase.
What Thermo says about this platform
Thermo Fisher built the TSQ Endura around an RF-Lens ion optics design, combining an ion beam guide with a neutral blocker and the quadrupole mass filter to cut noise and increase sensitivity. The instrument runs selected reaction monitoring at up to 500 SRM transitions per second, with as many as 30,000 definable SRM transitions available. Dynamic range extends across five orders of magnitude. The mass spectrometer weighs about 325 pounds and measures 41 by 38 by 37 inches.
What each module does
Liquid chromatograph (sold separately)
Separates the mixture and delivers a reproducible gradient to the source. This listing does not specify a bundled HPLC brand; a compatible front end is sold separately or paired at the bench.
Ion source
Converts the liquid eluent into gas-phase ions before they enter the RF-Lens ion optics.
Mass analyzer
An ion beam guide with a neutral blocker feeds two quadrupoles flanking a collision cell. The first selects a precursor, the cell fragments it, and the second measures a product ion for trace-level quantitation.
Vacuum and detection
Stages the ions from atmosphere to high vacuum, then counts them at the detector.
Technical detail
*OEM specifications for brand new instrument.
What “GenTech Certified” means
Refurbishment at GenTech is a defined process, not a wipe-down. Every system moves through the same five stages.
1. Disassembly and rebuild. Solution Scientists strip the instrument down, clean each module inside and out, and rebuild it from the frame up. They replace pump seals, pistons, and check valves to specification.
2. Configuration and new parts. Solution Scientists install the options and modules you selected and fit new wear parts throughout. They replace the detector lamp with a new one and reset the lamp hours.
3. Diagnostic and performance testing. Solution Scientists tune and calibrate the instrument, run system diagnostics, and confirm detector wavelength accuracy. They test full-system pressure and gradient performance against OEM and published benchmarks using known reference chemicals.
4. Delivery and installation. The instrument ships in protective packing with a one-year warranty option and professional installation available from a GenTech Solution Scientist.
Labs that run this system
The Thermo TSQ Endura is method-compatible across the techniques most regulated and research labs run every day. These are the application areas buyers ask about most.
PFAS testing
EPA Method 537.1 and similar state programs require quantitation of per- and polyfluoroalkyl substances in drinking water at low parts-per-trillion levels, a sensitivity range triple quadrupole MS is built to reach.
Pesticides and mycotoxins
Multi-residue pesticide panels and mycotoxin screens in food and cannabis testing often cover more than 100 compounds in a single run, each requiring the selectivity a triple quadrupole provides against a complex matrix background.
Trace impurities and cleaning validation
Pharmaceutical cleaning validation protocols confirm that equipment surfaces carry no detectable residue of the previous product, often down to sub-part-per-billion swab or rinse limits.
Quantitative toxicology
Forensic and clinical toxicology panels quantify drugs and metabolites in blood, urine, or tissue against legally defensible limits, where a triple quadrupole’s selectivity rules out false positives from matrix interferences.
GLP-grade quantitation
Good Laboratory Practice studies require documented, audit-ready quantitation with full method validation, a standard regulated bioanalysis labs run routinely on triple quadrupole platforms.
Additional Information
Documentation
Financing

Application Note: Quantitation of Immunosuppressant Drugs in Blood Utilizing a Triple Quadrupole Mass Spectrometer
Application Note: A Simple Method to Analyze Barbiturates in Urine Using a Triple Quadrupole Mass Spectrometer
TSQ Endura / TSQ Quantiva Pre-Installation Requirements Guide
TSQ Endura Triple-Stage Quadrupole Mass Spec Brochure
TSQ Endura Triple-Stage Quadrupole Mass Spectrometer Spec Sheet
TSQ Endura and TSQ Quantiva Hardware Manual
Transform Your Food Analysis
Challenges in Sample Preparation for Forensic Quantitative Screening of Over 120 Drugs of Abuse on a Triple Quadrupole Mass Spectrometer
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Need something else instead?
Replacing a failed pump or main board? Looking to upgrade your mass spec? Shop our inventory to find in-stock and performance-verified instruments to upgrade your lab.
[In this listing]
Thermo Scientific TSQ Endura Triple Quadrupole MS: Verified
Mechanical Pump: Verified
Warranty Coverage Extended Options Available: Included
Workstation with preloaded software: Included
[Each module is individually serialized and performance-verified before the stack is assembled and tested as a complete system.]
Analyzer: Triple quadrupole
SRM speed: Up to 500 SRM/sec
Definable SRMs: Up to 30,000
Dynamic range: 5 orders of magnitude
Ion optics: RF-Lens, ion beam guide with neutral blocker
Weight: 350 lbs
Dimensions: 60 × 60 × 60 in
Model: Endura
OEM: Thermo Scientific
Financing: Financing Options Available