USED THERMO FISHER SCIENTIFIC HYPERFORMA 50 L SINGLE-USE BIOREACTOR W

The Thermo Scientific™ HyPerforma™ 50 L Single-Use Bioreactor (S.U.B.) with Applikon® Controller is a fully integrated single-use stirred-tank bioreactor system designed for process development, pilot-scale production, and cGMP biomanufacturing. The system combines Thermo Fisher's stainless-steel bioreactor support vessel with a disposable BioProcess Container (BPC) and an Applikon PLC-based control platform for precise monitoring and automation of cell culture processes.

The 50 L HyPerforma S.U.B. supports batch, fed-batch, and perfusion cultures for mammalian, insect, and microbial cells. Its open-architecture design allows integration with multiple automation platforms while providing advanced control of pH, dissolved oxygen (DO), temperature, agitation, gas flow, and feeding strategies. Thermo also offered complete turnkey systems with integrated Applikon controllers, making this configuration a popular choice for upstream bioprocessing laboratories and pilot manufacturing facilities.

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Key Highlights

- 50 L single-use stirred-tank bioreactor
- Integrated Applikon® PLC controller
- Disposable BioProcess Container (BPC)
- Stainless-steel support vessel
- Batch, fed-batch, and perfusion capability
- AC or DC motor agitation (configuration dependent)
- Water-jacketed or electrically heated vessel options
- Automated control of pH, DO, temperature, agitation, and gas flow
- Compatible with electrochemical and single-use sensors
- Open architecture supporting DeltaV™, Siemens®, Allen-Bradley®, and PC-based control systems
- Suitable for cGMP manufacturing and process scale-up
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Applications / Uses

- Mammalian cell culture
- CHO cell production
- Vaccine manufacturing
- Monoclonal antibody production
- Cell and gene therapy process development
- Microbial fermentation
- Process optimization
- Perfusion culture
- Pilot-scale biomanufacturing
- Biopharmaceutical research
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Typical Specifications (Summary)

- Instrument Type: Single-Use Stirred-Tank Bioreactor
- Working Volume: Up to 50 L
- Bioreactor Vessel: Stainless-steel support vessel with disposable BPC
- Mixing: Overhead mechanical agitation
- Motor: AC or DC (configuration dependent)
- Heating: Water jacket or electric heating blanket
- Process Modes: Batch, Fed-Batch, Perfusion
- Control Parameters: pH, DO, Temperature, Agitation, Gas Flow, Pressure
- Sensors: Single-use and reusable pH, DO, and pressure sensors
- Controller: Applikon PLC eZ-Controller
- Power Supply: Typically 200–240 VAC, 50/60 Hz (configuration dependent)
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Typical Configuration Includes

- Thermo HyPerforma 50 L stainless-steel bioreactor vessel
- 50 L disposable BioProcess Container (BPC)
- Applikon controller cabinet
- Touchscreen/HMI
- Agitation drive
- Gas flow control system
- Mettler Toledo monitoring module (on many configurations)
- Temperature control/chiller
- Tubing assembliesShow moreShow lessClick to Request More Info

Type: Bioreactors